研究脑胶质瘤形成、发展及复发过程中重要的细胞分子机制;
2.探索脑肿瘤微环境以及开发免疫治疗的新策略
代表性论文(*通讯作者):
(1)Fanghui Lu, Ying Chen, Chuntao Zhao, Haibo Wang, Hong Bu, Peter Canoll and Q. Richard Lu*, et al., Olig2-Dependent Reciprocal Shift in PDGF and EGF Receptor Signaling Regulates Tumor Phenotype and Mitotic Growth in Malignant Glioma.Cancer Cell, 2016, 9;29(5):669-83.
(2)Yijie Sun, Yanyi Sun, Saichao Yue, Yaohe Wang,Fanghui Lu*. Histone Deacetylase Inhibitors in Cancer Therapy.Curr Top Med Chem, 2018,18(28):2420-2428.
(3)Jennifer Kosty,Fanghui Lu, Robert Kupp, Shwetal Mehta, Q. Richard Lu*, Harnessing OLIG2 function in tumorigenicity and plasticity to target malignant gliomas. Cell Cycle, 2017, 16(18): 1654-1660.
(4)Li He, Kun Yu,Fanghui Lu, Jiajia Wang, Laiman N. Wu, Q. Richard Lu*. Transcriptional Regulator ZEB2 Is Essential for Bergmann Glia Development. Journal of Neuroscience,2018, 2674-17.2018