学院领导
研究方向
陈昶

陈昶,男,副研究员,副教授。重庆市引进高层次人才。澳大利亚阿德莱德大学博士,华中科技大学同济医学院本科、硕士、博士后。2016年9月至今就职于重庆医科大学生命科学研究院。

联系方式: chenchang@cqmu.edu.cn

研究方向:

1.基于液相色谱-质谱联用的代谢组学方法开发及应用

2.妊娠期体内物质代谢和转运相关问题

主持项目:

1.国家自然科学基金面上项目(国家级,编号82071671):胆汁酸代谢异常致胃肠胰岛轴功能失衡在GDM发病中的作用机制研究2021.1.1-2024.12.31,55万元,在研。

2.超声医学工程国家重点实验室开放课题(省部级,批准号2022KFKT022):超声对体液中肽链形成的影响研究2022.9.7-2024.5.31,10万元,在研。

3.国家自然科学基金青年科学基金项目(国家级,编号81701477):FAM134B介导的内质网过度自噬导致钙离子异常释放在PE发病中的作用机制研究2018.1.1-2020.12.31,18万元,已结题。

4.中国博士后科学基金(国家级,编号2014M550396):2型糖尿病进程中的胆汁酸谱动态变化研究2014.4.1-2016.10.22,8万元,已结题。

代表论文:(#共同第一作者,*通讯作者)

1.Yun Li, Dan Zhang, Yan Mo, Teng Zeng, Tongzhi Wu, Lingqiao Liu, Hua Zhang*,Chang Chen*. Simultaneous determination of sex hormones and bile acids in rat plasma using a liquid chromatography- tandem mass spectrometry method. Journal ofPharmaceuticaland Biomedical Analysis (2023), 115139. doi:10.1016/j.jpba.2022.115139

2.Qingzhu Gao#, Bin Cheng#,Chang Chen#, Chong Lei#, Xue Lin, Dan Nie, Jingjing Li, Luyi Huang, Xiaosong Li, Kai Wang*, Ailong Huang*, Ni Tang*. Dysregulated glucuronic acid metabolism exacerbates hepatocellular carcinoma progression and metastasis through the TGFβ signalling pathway Clinical and Translational Medicine (2022), 12(8): e995. doi: 10.1002/ctm2.995

3.Xuyi Wang #,Chang Chen#, Cong Xie, Weikun Huang, Richard L. Young, Karen L. Jones,MichaelHorowitz, Christopher K. Rayner, Zilin Sun, Tongzhi Wu. Serum bile acid response to oral glucose is attenuated in patients with early type 2 diabetes and correlates with 2h plasma glucose in individuals without diabetes. Diabetes Obesity & Metabolism (2022), 24(6): 1132-1142. doi: 10.1111/dom.14683.

4.Jianan Zhu, Guangmin Song, Xiaobo Zhou, Ting-Li Han, Xinyang Yu, Hao Chen, Toby Mansell, Boris Novakovic, Philip N. Baker, Richard D. Cannon, Richard Saffery,Chang Chen*, Hua Zhang*. CD39/CD73 Dysregulation of Adenosine Metabolism Increases Decidual Natural Killer Cell Cytotoxicity: Implications in Unexplained Recurrent Spontaneous Abortion. Frontiers in Immunology (2022), 13:813218. doi: 10.3389/fimmu.2022.813218.

5.Jin Xiang#,Chang Chen#, Rui Liu#, Dongmei Gou#, Lei Chang, Haijun Deng, Qingzhu Gao, Wanjun Zhang, Lin Tuo, Xuanming Pan, Li Liang, Jie Xia, Luyi Huang, Ke Yao, Bohong Wang, Zeping Hu, Ailong Huang*, Kai Wang* & Ni Tang*. Gluconeogenic enzyme pck1 deficiency promotes chk2 o-glcnacylation and hepatocellular carcinoma growth upon glucose deprivation. Journal of Clinical Investigation (2021), 131(8):e144703. doi: 10.1172/JCI144703.