学院领导
师资队伍
吴兰香

吴兰香

吴兰香,女,研究员,博士生导师。2007年获大连医科大学生理学专业博士学位,同年进入重庆医科大学工作,2009~2012年在中南大学临床药理研究所周宏灏院士团队做博士后研究工作,2016~2017年赴美国西雅图华盛顿大学药学院做访问学者。主要从事恶性肿瘤精准诊疗相关生物标志物与治疗靶标研究工作,作为课题负责人承担了3项国家自然科学基金,以及中国博士后科学基金、重庆市自然科学基金等多项课题,发表SCI论文30余篇。

联系方式:lxwu@cqmu.edu.cn

主要研究方向:

1.恶性肿瘤靶向药物耐药性发生机制以及生物标志物研究;

2.恶性肿瘤免疫治疗新靶点研究。

代表性论文(#第一作者,*通讯作者):

1.Huang Yutang#, Du Yan#, Zheng Yujie#, Wen Chunjie, Zou Hecun, Huang Jiafeng, Zhou Honghao, Zhao Hongbo*,Wu Lanxiang*. Ct-OATP1B3 promotes high-grade serous ovarian cancer metastasis by regulation of fatty acid beta-oxidation and oxidative phosphorylation. Cell Death Dis. 2022, 13:556.

2.He Shuai#, Shi Jingjing, Zhou Honghao, Li Qingling*,Wu Lanxiang*. Lnc-ABCA12-8 confers acquired resistance to gefitinib in non-small cell lung cancer by regulating the alternative splicing of fibronectin 1 in the IIICS region. Cancer Gene Ther. 2022 Jun 14. doi: 10.1038/s41417-022-00483-0.

3.Huang Yutang#, Dai Yi#, Wen Chunjie, He Shuai, Shi Jingjing, Zhao Dezhang,Wu Lanxiang*, Zhou Honghao. circSETD3 Contributes to Acquired Resistance to Gefitinib in Non-Small-Cell Lung Cancer by Targeting the miR-520h/ABCG2 Pathway. Mol Ther Nucleic Acids. 2020, 4;21:885-899.

4.Zhao Hongbo#, Huang Yutang, Shi Jingjing, Dai Yi,Wu Lanxiang*, Zhou Honghao. ABCC10 Plays a Significant Role in the Transport of Gefitinib and Contributes to Acquired Resistance to Gefitinib in NSCLC. Front Pharmacol. 2018, 9:1312.

5.Wu Lanxiang#, Wen Chunjie, Li Ying, Zhang Xue, Shao Yingying, Yang Zhu, Zhou Honghao. Interindividual epigenetic variation in ABCB1 promoter and its relationship with ABCB1 expression and function in healthy Chinese subjects. Br J Clin Pharmacol. 2015, 80:1109-1121.